Evolution and immunology of infectious diseases: what's new? An E-debate.

Recombinant Production of a Novel Fusion Protein: Listeriolysin O Fragment Fused to S1 Subunit Of Pertussis Toxin

Background: Some resources have suggested that genetically inactivated pertussis toxoid (PTs) bear a more protective effect than chemically inactivated products. This study aimed to produce new version of PT, by cloning an inactive pertussis toxin S1 subunit (PTS1) in a fusion form with N-terminal half of the listeriolysin O (LLO) pore-forming toxin. Methods: Deposited pdb structure file of the...

Evolution and immunology of infectious diseases: what's new?

Jean-Baptiste André a, Sunetra Gupta b, Steven Frank c, Michel Tibayrenc d,∗ a Laboratoire Génome, Populations, Interactions, Adaptation UMR 5171, USTL, Place Eugène Bataillon, 34095 Montpellier Cedex 5, France b Department of Zoology, University of Oxford, Oxford OX1 3PS, UK c Department of Ecology and Evolutionary, UC Irvine, 321 Steinhaus Hall, Irvine, CA 92697-2525, USA d Genetics and Evolu...

2002 Neodarwinism and infectious diseases transmission: an e-debate.

2002 Neodarwinism and infectious diseases transmission: An e-debate Francisco J. Ayala a, Emily Lyons b, Yannis Michalakis c, Michel Tibayrenc c,∗ a Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA b Malaria Population Genetics and Evolution, Peter Medawar Building for Pathogen Research, Department of Zoology, University of Oxford, South Parks Road...

Population genetics and population biology: what did they bring to the epidemiology of transmissible diseases? An e-debate.

The definition of the CDC for molecular epidemiology is: “the various techniques derived from immunology, biochemistry, and genetics for typing or subtyping pathogens”. This definition is technology-based and does not make any reference to evolutionary genetic concepts. Do you think that this approach is misleading for medical and epidemiological applications, or do you think that molecular epi...

Successful Treatment of Refractory Behçet's Disease with the TNF-α Blocker Infliximab